News​

cortisol measurements in Beagle dogs - new publication

Feb 2022

New results just published in Journal of Pharmacological and Toxicological Methods show that when the blood samples are collected in a completely stress-free way, blood cortisol levels in dogs are significantly lower than would be expected.

The blood samples were collected using our novel Fluispotter® technology which allows blood samples to be taken automatically from free roaming animals without human intervention or disturbance.

Previously, measurements of cortisol levels in dog’s blood have been performed through venipuncture or via tethered animals, that have been stressed from the handling or from being connected to a tether with resulting discomfort and restrictions on movement and group housing.

Cortisol is a powerful and sensitive marker of stress, and these results show that for the first time it is now possible to obtain many blood samples without disturbing or stressing the animals as measured by the most sensitive marker of stress.

The results show that Fluispotter® opens new ways of reducing pain, fear, and discomfort for animals in animal trials, and gives the research community a new powerful tool to further 3R efforts.

Organizations serious about animal welfare and ethical laboratory animal experimentation can, by using Fluispotter®, improve output and quality of their animal trials while reducing the discomfort and stress of their animals.

Fluispotter® is available for international sale.

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Fluisense completes ISO 13485:2016 certification​

Dec 2021

It has been a goal since the beginning of Fluisense to develop and maintain a quality management system in accordance with ISO 13485 to ensure that records are kept which correctly reflect the development and manufacturing of devices in Fluisense and it is a major milestone to finally achieve the certification. This would not have been possible without contribution from the whole team of current and former employees.

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Fluisense has a certified Class 8 clean-room where we can do contract assembly and packaging of sterile medical devices. Examples are vascular catheters, infusion pumps and infusion bags. We can also do silicone molding, primary packaging, etc. of small scale batches and prototypes for clinical - and pre-clinical trials.

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​Read more about which standards we have implemented and can apply on your product and which processes we can handle in the clean-room and in ESD area here.

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clinical investigation initiated

​Feb 2021

Fluisense has initiated the healthy volunteer study at DanTrials to test safety and performance of Fluispotter. 

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This will be the first ever trial to test fully automated serial blood sampling from a human with a wearable device fixed on the upper arm. 

patent update

​Jan 2021

Fluisense has been grated patent in the US:

US10895253 (B2) was granted in Jan 2021 covering a micropump for constant infusion.

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patent update

​April 2020

​Fluisense has been granted patents in Europe, Japan and US:

US10286149 (B2) was granted in May 2018 covering the initial invention of unidirectional flow and a flow-controller.

JP6393309 (B2) was granted in Aug 2018 covering the entire Fluispotter system.

US10064575 (B2) was granted in Sept 2018 covering the multilumen catheter.

JP6595451 (B2) was granted in Oct 2019 covering the multilumen catheter.

​EP3408537 (A1) was granted in Apr 2020 covering one of the micropump technologies developed for Fluispotter

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PATENT GRANTED IN EUROPE

​December 21 2016

Fluisense ApS has been granted European patent on our Multilumen Catheter. Patent no. EP 2884895. Priority claimed in April 2013.

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PATENT GRANTED IN EUROPE

​May 25 2016

Fluisense ApS has been granted European patent on Fluispotter System. Patent no. EP 2884896. Priority claimed in April 2013.

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​innovation fund denmark is investing in the clinical validation of Fluispotter

February 18 2016

​Innovation Fund Denmark has granted Fluisense 5.8 mio DKK to test the clinical value of Fluispotter as a diagnostic tool in patients. The project is a three year collaboration between Fluisense, Dept. of Clinical Biochemistry and Dept. of Endocrinology at Rigshospitalet and Dept. of Paediatrics at Herlev Hospital. The device will be used to measure stress hormones in adult and adolescent patients suffering from hormonal disorders that are very challenging and time consuming to diagnose with available procedures. For more information about the project please contact Project Manager Malene Schrøder, COO.

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For a Danish project description, please refer to the website of Innovation Fund Denmark:

http://innovationsfonden.dk/en/node/760

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Patent granted in japan

July 31 2015

​Fluisense ApS has got granted and validated patent in Japan. The patent was published in Patent Gazette on July 8th 2015. Patent no. JP 5746973. Priority claimed in December 2008.

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Two International patent applications published

​October 24 2014

Two international patent applications have been published under PCT as 'WO 2014-169923 Multi Lumen Catheter' and 'WO 2014-169924 Improved Fluid Sampling System'.

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First successful 24-hour study with Fluispotter​

July 4 2014​

​The small wearable Fluispotter has just finished taking a full 24-hour blood profile from a freely moving pig housed in its pen. The 70 gram device was mounted on the pig under full anaesthesia and placed securely in the pocket of a jacket. After the surgery the pig was replaced to its pen to wake up.

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Fluispotter performed as planned for the duration of the study; hence it maintained patency of the catheter and extracted blood samples at the predetermined time points. The sampling was fully automatic and unsupervised.

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The pig was dosed with Acetaminophen and the resulting Dried Blood Spot samples will be analyzed at the University of Copenhagen and will generate a PK-curve.​

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